Regulation of fetal tolerance by KIR +regulatory CD8 +T cells in human pregnancy
نویسندگان
چکیده
Abstract Immune responses during pregnancy need to be precisely regulated protect the fetus from microbial infections and maintain tolerance for semi-allogeneic fetus. However, mechanisms regulating fetal are not well understood. Recently we have identified KIR +CD8 +T cells as a previously unappreciated subset with regulatory functions in humans suppress harmful self-reactivity. Therefore, asked whether also play role inducing immune pregnancy. We first observed an increased frequency of cells, but CD4 +regulatory T (Tregs), peripheral blood pregnant women at second trimester compared age-matched nonpregnant females. Interestingly, those male had even higher level than ones female In vitro, found that can CD8 specific H-Y antigens (encoded by Y chromosome) only mothers induction carrying may additional allogenic triggered chromosome Moreover, expand, lose memory features gain cytotoxic capacity along gestation their levels maintained postpartum. addition, numbers these suppressive correlated disorders, such spontaneous abortion or pre-eclampsia. Taken together, our findings suggest important maintenance suppressing alloreactive fetus-specific therefore they useful predictive biomarkers drug targets human disorders. Supported Howard Hughes Medical Institute.
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ژورنال
عنوان ژورنال: Journal of Immunology
سال: 2023
ISSN: ['1550-6606', '0022-1767']
DOI: https://doi.org/10.4049/jimmunol.210.supp.226.06